Application | Comment | Organism |
---|---|---|
diagnostics | the MMP-2/TIMP-2 ratio may be of value in evaluating the prognosis in canine oronasal cavity tumors | Canis lupus familiaris |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
TIMP-2 | - |
Canis lupus familiaris |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | MMP-2 is secreted | Canis lupus familiaris | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Canis lupus familiaris | |
Zn2+ | dependent on | Canis lupus familiaris |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | Canis lupus familiaris | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the proMMP-2 precursor form is cleaved by MT1-MMP to produce an intermediate MMP-2,subsequently, this molecule autocatalytically converts itself into mature MMP-2 | Canis lupus familiaris |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
melanoma cell | - |
Canis lupus familiaris | - |
additional information | expression analysis of MMP-2 in dog tumor tissues, overview | Canis lupus familiaris | - |
oronasal squamous cell carcinoma cell | regional lymph node invasion and distant metastases are more frequently observed in the MMP-2 positive cases, the MMP-2/TIMP-2 ratio is also positively correlated with MMP-2 activity, overview | Canis lupus familiaris | - |
squamous cell carcinoma cell | - |
Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | - |
Canis lupus familiaris | ? | - |
? | |
Gelatin + H2O | gelatin zymography | Canis lupus familiaris | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-2 | - |
Canis lupus familiaris |
MMP-2 | - |
Canis lupus familiaris |